Predictors of COVID-19 severity: a systematic review and meta-analysis
| Autor: | Abdullah Azmy, Firzan Nainu, Richi Aditya, Monika Sitio, Radhitio Adi Nugroho, Yennie Ayu Setianingsih, Sri Masyeni, Hamid Hunaif Dhofi Alluza, Nikma Alfi Rosida, Adam Hartono, Suhendra Suhendra, Romi Hamdani, Jonny Karunia Fajar, Ali A. Rabaan, Muchamad Muchlas, Fransiskus Xaverius Meku, Muhammad Ilmawan, Abram L. Wagner, Camoya Gersom, Mayasari Mayasari, Firman Prastiwi, Mudatsir Mudatsir, Galih Dwi Jayanto, Gatot Soegiarto, Kartika Agustina, Kuldeep Dhama, Anita Surya Santoso, Laksmi Wulandari, Daniel Alexander Suseno, Mustofa Mustofa, Harapan Harapan, Hamdan Yuwafi Naim, Bagus Aulia Mahdi, Yeni Purnamasari |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
viruses Disease Anorexia 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Procalcitonin 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Blood urea nitrogen General Immunology and Microbiology medicine.diagnostic_test business.industry Respiratory disease virus diseases General Medicine biochemical phenomena metabolism and nutrition medicine.disease digestive system diseases Erythrocyte sedimentation rate Meta-analysis medicine.symptom business |
| Zdroj: | F1000Research. 9:1107 |
| ISSN: | 2046-1402 |
| Popis: | Background: The unpredictability of the progression of coronavirus disease 2019 (COVID-19) may be attributed to the low precision of the tools used to predict the prognosis of this disease. Objective: To identify the predictors associated with poor clinical outcomes in patients with COVID-19. Methods: Relevant articles from PubMed, Embase, Cochrane, and Web of Science were searched as of April 5, 2020. The quality of the included papers was appraised using the Newcastle-Ottawa scale (NOS). Data of interest were collected and evaluated for their compatibility for the meta-analysis. Cumulative calculations to determine the correlation and effect estimates were performed using the Z test. Results: In total, 19 papers recording 1,934 mild and 1,644 severe cases of COVID-19 were included. Based on the initial evaluation, 62 potential risk factors were identified for the meta-analysis. Several comorbidities, including chronic respiratory disease, cardiovascular disease, diabetes mellitus, and hypertension were observed more frequent among patients with severe COVID-19 than with the mild ones. Compared to the mild form, severe COVID-19 was associated with symptoms such as dyspnea, anorexia, fatigue, increased respiratory rate, and high systolic blood pressure. Lower levels of lymphocytes and hemoglobin; elevated levels of leukocytes, aspartate aminotransferase, alanine aminotransferase, blood creatinine, blood urea nitrogen, high-sensitivity troponin, creatine kinase, high-sensitivity C-reactive protein, interleukin 6, D-dimer, ferritin, lactate dehydrogenase, and procalcitonin; and a high erythrocyte sedimentation rate were also associated with severe COVID-19. Conclusion: More than 30 risk factors are associated with a higher risk of severe COVID-19. These may serve as useful baseline parameters in the development of prediction tools for COVID-19 prognosis. |
| Databáze: | OpenAIRE |
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