Re-emergence of topical retinol in dermatology

Autor:	Lorraine H. Kligman, EH Gans
Rok vydání:	2000
Předmět:	Vitamin medicine.medical_specialty Erythema business.industry medicine.drug_class Retinoic acid Retinol Photodermatosis Dermatology medicine.disease Intrinsic and extrinsic aging Clinical trial chemistry.chemical_compound chemistry medicine Retinoid medicine.symptom business
Zdroj:	Journal of Dermatological Treatment. 11:47-52
ISSN:	1471-1753 0954-6634
DOI:	10.1080/09546630050517685
Popis:	BACKGROUND: All-trans-retinol was the first vitamin to be synthesized in the laboratory. Dermatologic research with this agent, first begun in the 1960s, was discontinued because of its instability. Investigations since then have focused primarily on a metabolite of vitamin A, all trans-retinoic acid, for the treatment of various dermatological disorders. TREATMENT: While topically applied retinoic acid is effective in reducing the signs of intrinsic aging and repairing photodamaged skin, depending on the concentration it causes a number of irritant effects, including erythema, peeling, dryness, and pruritus in some patients. This drawback stimulated renewed efforts to find a less irritating retinoid. ADVANCES: As a result of advances in the cosmetic industry, retinol is now being produced in a stable formulation, and is again commanding the attention of investigators. CONCLUSION: Clinical trials conducted so far indicate that, like retinoic acid, retinol can induce changes that have a beneficial effect o...
Databáze:	OpenAIRE
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