Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides

Autor:	Martin Doležal, Antonín Lyčka, Vladimír Buchta, Želmíra Odlerová, Jiří Hartl
Rok vydání:	1995
Předmět:	medicine.drug_class Elemental analysis Chemistry medicine Nucleophilic substitution Proton NMR General Chemistry Antimycobacterial Medicinal chemistry
Zdroj:	Collection of Czechoslovak Chemical Communications. 60:1236-1241
ISSN:	1212-6950 0010-0765
DOI:	10.1135/cccc19951236
Popis:	Nucleophilic substitution of 3-chloro-5-cyano-2-pyrazinecarboxamide by substituted anilines afforded substituted 3-arylamino-5-cyano-2-pyrazinecarboxamides I-X. The structures of compounds were confirmed by elemental analysis, UV, IR and 1H NMR spectra. The assessment of in vitro antimycotic and antimycobacterial activities of the compounds was carried out. The highest antituberculotic activity against M. tuberculosis in this series was shown by 3-anilino- 5-cyano-2-pyrazinecarboxamide (I), whose efficacy was the same as that of pyrazinecarboxamide.
Databáze:	OpenAIRE
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