Acromegaly and Sleep Apnea

Autor: J.J. Blanco Pérez, A. Mato Mato, M.A. Blanco-Ramos, A. Souto Fernández, J. Lamela López, C. Zamarrón Sanz
Rok vydání: 2004
Předmět:
Zdroj: Archivos de Bronconeumología ((English Edition)). 40:355-359
ISSN: 1579-2129
DOI: 10.1016/s1579-2129(06)60320-0
Popis: Objective Acromegaly is often associated with sleep apnea-hypopnea syndrome (SAHS). The purpose of this study was to understand the prevalence of SAHS in patients with acromegaly and define the characteristics of acromegalic patients with and without SAHS. Patients and methods The study enrolled 17 patients (11 women and 6 men) residing in the province of Ourense, Spain, who were diagnosed with acromegaly. All patients underwent overnight polysomnography in a sleep laboratory. In addition, growth hormone and insulin-like growth factor 1 levels were assessed. Sixteen of the patients underwent cephalometric study. Results The average age of the patients was 58 years (95% confidence interval [CI], 52-63). The average body mass index was 31 (95% CI, 29-34) and average neck circumference was 41 (95% CI, 39-43). Ten patients (58.8%) had an apnea-hypopnea index (AHI) greater than 10. Nine had obstructive apnea and one had central apnea. Seven (5 with an AHI>10 and 2 with an AHI 10 and Epworth>10). No correlation was found between an AHI greater than 10 and hormonal activity ( P = .082). The mean growth hormone level for patients with an AHI greater than 10 was 4.8 (95% CI, 0.5-9) and the mean for those with an AHI less than 10 was 12 (95% CI, 2-27). Fifty percent of the patients were treated with a somatostatin analog and half of those treated exhibited apnea ( P = .302). No cephalometric differences related to the presence of apneas were found. Conclusions We found a high prevalence of sleep apneas (58.8%) and SAHS (29.4%), and central apneas were rare. We found no correlation between hormone activity level and the presence of SAHS. The incidence of SAHS was the same in somatostatin analog treated and untreated patients. Cephalometric variables did not distinguish between acromegalic patients with and without SAHS.
Databáze: OpenAIRE
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