An evaluation of the diagnostic adequacy and immunocytochemistry of manual liquid-based smears in breast aspirates
| Autor: | Colleen A. Wright, J Bezuidenhout, P.T. Schubert, A.L. Shebemba |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test Epidemiology business.industry Immunocytochemistry Dermatology Infectious Diseases Fine-needle aspiration Cytology Liquid-based cytology Aspiration biopsy medicine Liquid based Radiology Oestrogen receptor Prospective cohort study business |
| Zdroj: | Southern African Journal of Epidemiology and Infection. 28:117-121 |
| ISSN: | 1015-8782 |
| DOI: | 10.1080/10158782.2013.11441530 |
| Popis: | The aim of this study was to determine if the Syner-Med®/Cell-Solutions® liquid-based cytology (LBC) technique would provide adequate diagnostic material when applied to breast fne-needle aspiration biopsy (FNAB) specimens and to determine its suitability for immunocytochemistry. A prospective study was undertaken of 38 consecutive patients who underwent FNAB of breast masses in the Fine Needle Aspiration Clinic at Tygerberg Hospital, Cape Town, over a period of six months. Conventional smear cytology slides (CSC) were formulated and the material that remained in the needle was used to prepare the LBC SynerMed®/Cell-Solutions® slides. The CSC and LBC slides were evaluated by two pathologists. The assessed parameters were cellularity, background and representative diagnostic material. Immunocytochemical stains for pancytokeratin (MNF-116) and oestrogen receptor were performed in each case. In 33 cases (87%), LBC compared favourably with CSC. Adequacy rates of 84.2% for CSC and 76.3% for LBC were found. A d... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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