Decidual glycodelin-A polarizes human monocytes towards a decidual macrophage-like phenotype via siglec-7
| Autor: | Jian Wu, Markku Seppälä, Kungfeng Bai, Philip C.N. Chiu, Kai-Fai Lee, Ernest Hung Yu Ng, William S.B. Yeung, Hannu Koistinen, Madhavi Vijayan, Cheuk-Lun Lee, Vera H.H. Wong, Xia Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Cell type 030219 obstetrics & reproductive medicine Decidua Trophoblast SIGLEC Cell Biology Biology Cell biology Immune tolerance 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Placenta embryonic structures medicine PAEP Macrophage 030304 developmental biology |
| Zdroj: | Journal of Cell Science. |
| ISSN: | 1477-9137 0021-9533 |
| Popis: | Decidual macrophages constitute 20-30% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs) are associated with fetal loss and pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs in a decidua-specific microenvironment. Despite their important roles in pregnancy, the exact factors that regulate the differentiation into dMs remain unclear. Glycodelin-A (PAEP, hereafter referred to as GdA) is a glycoprotein that is abundantly present in the decidua, and plays an important role in fetomaternal defense and placental development. It modulates the differentiation and activity of several immune cell types residing in the decidua. In this study, we demonstrated that GdA induces the differentiation of human monocytes into dM-like phenotypes in terms of transcriptome, cell surface marker expression, secretome, and regulation of trophoblast and endothelial cell functions. We found that Sialic acid-binding Ig-like lectin 7 (Siglec-7) mediates the binding and biological actions of GdA in a sialic acid-dependent manner. We, therefore, suggest that GdA, induces the polarization of monocytes into dMs to regulate fetomaternal tolerance and placental development. |
| Databáze: | OpenAIRE |
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