ON THE MECHANISM OF OXYGEN INSERTION CATALYZED BY CYTOCHROME P-450. HYDROXYLATION WITH PARTIAL ALLYLIC REARRANGEMENT

Autor:	Oluwamuye F. Akinbote, John T. Groves, Guillermina E. Avaria
Rok vydání:	1980
Předmět:	Allylic rearrangement Cytochrome biology organic chemicals Cyclohexene chemistry.chemical_element Medicinal chemistry Catalysis Hydroxylation chemistry.chemical_compound Chromium chemistry Cumene hydroperoxide biology.protein Organic chemistry Cyclohexene oxide
DOI:	10.1016/b978-0-12-187701-9.50050-4
Popis:	The cumene hydroperoxide dependent oxidation of cyclohexene catalyzed cytochrome P-450 produced cyclohexene oxide and cyclohexenol. Catalytic Systems containing chlorotetraphenyl-porphinatoiron(III)-iodosylbenzene and chlorotetraphenylpor-phinatochromium (III)-iodosylbenzene gave the same products. The oxidation of 1,2-dideuterocyclohexene by these systems gave cyclohexenol with various degrees of allylic rearrangement. With the chromium catalyst nearly complete, allylic scrambling was observed whereas the iron catalyst and cytochrome P-450 gave only partial equilibration. A mechanism involving caged radical intermediates is presented to account for these results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd09d5130e16034e9d292bcb9e4696fc https://doi.org/10.1016/b978-0-12-187701-9.50050-4 Zobrazit plný text záznamu