| Autor: | B. K. Glaser, G. S. Ranhotra, Brown Se, Schoening P, J. A. Gelroth |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Incidence (epidemiology) chemistry.chemical_element Tumor initiation Calcium B vitamins chemistry.chemical_compound Endocrinology chemistry Biochemistry Chemistry (miscellaneous) Internal medicine Dimethylhydrazine Medicine Tumor promotion Cellulose business Food Science Glucan |
| Zdroj: | Plant Foods for Human Nutrition. 54:295-303 |
| ISSN: | 0921-9668 |
| DOI: | 10.1023/a:1008149107282 |
| Popis: | In a 30-week preliminary study and a follow-up 22-week study (2 × 2 factorial), dimethylhydrazine (DMH)injections effectively induced colon tumors in Fischer-344rats. How this incidence of colon tumors might be affected by cellulose (preliminary study) or by calcium and folic acid (follow-up study) was examined. Cellulose in the dietappeared to provide some protection against DMH-induced colon tumors, but the protective effect of calcium was moreevident; normal levels of calcium (500 mg per 100 g diet), but not of folic acid (0.1 mg per 100 g diet), provided protection against colon tumors. The effect due to calciumwas observed whether viewed in terms of total number of tumors (p lt 0.01) or number of tumors per tumor-bearing rat(p < 0.01). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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