Synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one via molybdenum hexacarbonyl mediated CO gas- and ligand free carbonylative reactions
| Autor: | T. Krishna, Akula Raghunadh, J. Rajesh, A. Venkateswara Rao, V. N. Murthy, J. Subba Rao |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Decarboxylation General Chemical Engineering Iodobenzene Monoxide General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Molybdenum hexacarbonyl 0104 chemical sciences Catalysis chemistry.chemical_compound Nucleophile chemistry Organic chemistry Amine gas treating Carbonylation |
| Zdroj: | RSC Advances. 6:67534-67539 |
| ISSN: | 2046-2069 |
| Popis: | Carbon monoxide gas and ligand-free conditions were developed for the synthesis of 2-hydroxy-3-alkyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one via catalytic carbonylation with molybdenum hexacarbonyl as an efficient carbonylating agent for the three-component reaction of isatoic anhydride, amine, iodobenzene. Mo(CO)6 is a solid carbon monoxide source. The quinazolinone synthesis proceeds via a sequential series of reactions such as nucleophilic attack of the amine group on the carbonyl group of isatoic anhydride followed by ring opening, subsequent decarboxylation, carbonylation and heterocyclization. |
| Databáze: | OpenAIRE |
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