Abstract 1630: Uric Acid Revisited: Interrelationships with Low-Grade Inflammation, Adiponectin and Arterial Stiffness in Essential Hypertension
| Autor: | Costas Tsioufis, Dimitris Chatzis, Dimitris Tousoulis, Kyriakos Dimitriadis, Ioannis Kallikazaros, Christodoulos Stefanadis, Dimitris Tsiachris, Karmen Vasiliadou |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Adiponectin business.industry medicine.disease Essential hypertension Low grade inflammation chemistry.chemical_compound chemistry Physiology (medical) Internal medicine Arterial stiffness medicine Cardiology Uric acid Subclinical inflammation Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 116 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Introduction: Increased uric acid (UA) levels are associated with high cardiovascular risk, while subclinical inflammation, arterial stiffening and hypoadiponectinemia contribute to atherosclerosis progression. Hypothesis: Serum UA levels may be related to high-sensitivity C-reactive protein (hs-CRP), adiponectin and arterial stiffness in essential hypertensives. Methods: In our population of 292 newly diagnosed untreated non-diabetic patients with stage I to II essential hypertension [190 men, aged 50 years, office blood pressure (BP)=148/95 mmHg], the distribution of UA was split by the median (5.3 mg/dl) and accordingly subjects were classified into those with high and low values. In all participants, arterial stiffness was evaluated on the basis of carotid to femoral pulse wave velocity (PWV), by means of a computerized method (Complior SP). Results: Patients with high UA (n=143) compared to those with low UA (n=149) exhibited higher 24-h systolic BP (139±12 vs 132±11 mmHg, p Conclusions: Increased UA levels in essential hypertension are paralleled by a state of pronounced inflammatory activation, hypoadiponectinemia and accelerated arterial stiffening. These findings suggest that UA is interrelated with diverse mediators of vascular dysfunction, underscoring its pluripotent nature in the progression of the hypertensive atherosclerotic disease. |
| Databáze: | OpenAIRE |
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