New amino acid porphyrin derivatives. Part II: DNA binding studies

Autor:	Gilles Anneheim-Herbelin, A. Gaudemer, Nathalie Bône, Catherine Verchère-Béaur, Martine Perrée-Fauvet, Eric Tarnaud
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Organic Chemistry Intercalation (chemistry) Cationic polymerization Ring (chemistry) Biochemistry Porphyrin Amino acid chemistry.chemical_compound Drug Discovery polycyclic compounds heterocyclic compounds DNA
Zdroj:	Tetrahedron. 52:13589-13604
ISSN:	0040-4020
Popis:	Binding to a variety of natural and synthetic DNAs by cationic water-soluble porphyrins - having three N-methylpyridynium and one amino-acid derivatized phenyl ring as meso substituents - has been investigated. These studies indicate that amino acid porphyrin derivatives are able to intercalate into calf thymus DNA, but not as readily as meso -tetrakis-(N-methyl-4-pyridiniumyl)porphyrin (H 2 TMP y P-4). This lowering of affinity for intercalation may be due to the presence of only three positive charges on the porphyrin ion and/or an increased specificity towards specific DNA sequences arising from amino acid linkage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dcecb3ba8130cf173b7bdbd938eea4b3 https://doi.org/10.1016/0040-4020(96)00833-2 Zobrazit plný text záznamu Full Text from ScienceDirect