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Europäische Wissenschaftliche Gesellschaft Home About the Journal Peer Review Editorial Board For Authors Reviewer Recognition Archiv Kontakt Impressum EWG e.V. indexing in the Clarivate Analytics indexing in the Emerging Sources Citation Index Crossref Member Badge Erfolgreich durch internationale Zusammenarbeit MORPHOLOGY, PATHOLOGY, PHYSIOLOGY Cite as: Archiv EuroMedica. 2022. 12; 3: e1. DOI 10.35630/2199-885X/2022/12/3.2 Received 07 March 2022; Received in revised form 11 April 2022; Accepted 13 April 2022 THE LEVEL OF OXIDATIVE STRESS METABOLITES IN AN EXPERIMENTAL MODEL WITH PERIODONTITIS Tatyana Tarasova1 orcid id logo , Larisa Balykova1 orcid id logo , Dalila Khaydar2 orcid id logo, Olga Gurova2 orcid id logo, Alexey Zakhvatov1 orcid id logo, Elina Korovyakova2 orcid id logo, Larisa Mosina1, Roman Tarasov1, Maria Francisca Alekseeva3 1National Research Ogarev Mordovia State University, Saransk; 2Peoples' Friendship University of Russia, Moscow; 3Pirogov Russian National Research Medical University, Moscow, Russia download article (pdf) 9023060@mail.ru ABSTRACT In people worldwide, chronic periodontitis occurs in 10-15% of cases. Prolonged inflammation of periodontal tissues contributes to the formation of oxidative stress. The purpose of this study was to evaluate the level of malondialdehyde and superoxide dismutase (as indicators of oxidative stress) in periodontitis in rats. For this, in the main group of rats (n=10) a model of ligature periodontitis was created. The control group of rats (n=10) was intact. As a result, in periodontitis, the level of malondialdehyde doubled. We also found an inverse relationship between the level of lipid damage and superoxide dismutase activity. Conclusions. The level of metabolites of redox processes is significantly increased in periodontitis. This confirms a significant increase in the indicators of malondialdehyde. A decrease in superoxide dismutase activity leads to a low antioxidant status in rats. |
