Re-enter the syn-(Me,I)Bimane: A Gateway to Bimane Derivatives with Extended π-Systems

Autor:	Flavio Grynszpan, Joy Karmakar, Oleg Szumski
Rok vydání:	2021
Předmět:	chemistry.chemical_compound biology Bimane Stereochemistry Chemistry Ethynylbenzaldehyde Organic Chemistry Aldolase A biology.protein Derivatization
Zdroj:	Synlett. 32:1141-1145
ISSN:	1437-2096 0936-5214
Popis:	syn-α-Diiodobimane (syn-(R2,I)B) is a key intermediate for the derivatization of the bimane core in the α-positions. Here we describe an expeditious method to prepare symmetric α-bimane derivatives, such as syn-(R2,I)B, as well as unsymmetric ones. Our strategy turns the synthesis of α derivatives with extended π-systems practical and affordable. We applied this approach to the synthesis of ethynylbenzaldehyde bearing bimanes as potential selective probes for aldolase class I enzymes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dcdea0b3c84e147c5763d4a7cce90249 https://doi.org/10.1055/s-0040-1706045 Zobrazit plný text záznamu