Correlation between Lipid-Associated Sialic Acid and Tumor Burden in Melanoma
| Autor: | M. B. Clark, S. Hotchkiss, Antonio C. Buzaid, Alan B. Sandler, C. L. Hayden, Wen-Jen Poo, J. Scinto |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Clinical Biochemistry Tumor burden Disease Biology Pathology and Forensic Medicine Correlation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Lipid-associated sialic acid Tumor marker Melanoma Significant difference medicine.disease Sialic acid 030104 developmental biology chemistry 030220 oncology & carcinogenesis Immunology |
| Zdroj: | The International Journal of Biological Markers. 9:247-250 |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/172460089400900408 |
| Popis: | Recent studies have suggested that lipid-associated sialic acid (LSA) may be a useful tumor marker for monitoring patients with melanoma, but the relationship between LSA and tumor burden has not been previously studied. We therefore examined LSA levels in 240 patients of whom 169 had no clinical evidence of disease (NED) and 71 had metastatic disease. There was a statistically significant difference in LSA levels in patients with NED compared with metastatic disease as well as those with high tumor burden compared with low or intermediate tumor burden. There was no difference between the groups with low and intermediate tumor burden. An LSA level of 25 mg/dl provided a positive predictive value of 70% and a negative value of approximately 80%. Our data show that LSA levels correlate with tumor burden in patients with melanoma. |
| Databáze: | OpenAIRE |
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