| Autor: |
Trinitat Cambras, Maria Fernanda Zerón-Rugerio, Antoni Díez-Noguera, Maria Cleofe Zaragoza, Joan Carles Domingo, Ramon Sanmartin-Sentañes, Jose Alegre-Martín, Jesus Castro-Marrero |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2044838/v1 |
| Popis: |
Purpose There is accumulating evidence of autonomic dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the relationship between autonomic responses using an orthostatic test, skin temperature circadian variations, and circulating endothelial biomarkers in ME/CFS. Methods Sixty-seven adult female ME/CFS patients and 48 matched healthy controls were enrolled. Demographic and clinical characteristics suggestive of autonomic disturbances were assessed using validated self-reported outcome measures. Postural changes in blood pressure [BP], heart rate [HR], and wrist temperature (WT) were recorded during the orthostatic test. Actigraphy during one week was used to determine the 24-hour profile of peripheral temperature and motor activity. Circulating endothelial biomarkers were also measured as indicators of endothelial functioning. Results ME/CFS patients showed higher BP and HR values than healthy controls at rest (p p p p p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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