Prophylactic tranexamic acid in parturients at low risk for post-partum haemorrhage: systematic review and meta-analysis

Autor:	S. Klöhr, J. Böhmer, Rolf Rossaint, J. W. Dudenhausen, M. Heesen, Sebastian Straube, M. Van de Velde
Rok vydání:	2014
Předmět:	030219 obstetrics & reproductive medicine Blood transfusion business.industry medicine.medical_treatment General Medicine medicine.disease Placebo Thrombosis 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine Relative risk Meta-analysis Antifibrinolytic agent Anesthesia Medicine 030212 general & internal medicine business Adverse effect Tranexamic acid medicine.drug
Zdroj:	Acta Anaesthesiologica Scandinavica. 58:1075-1085
ISSN:	0001-5172
DOI:	10.1111/aas.12341
Popis:	Tranexamic acid is effective in reducing blood loss during various types of surgery and after trauma. No compelling evidence has yet been presented for post-partum haemorrhage. A systematic literature search of relevant databases was performed to identify trials that assessed blood loss and transfusion incidence after tranexamic acid administration for post-partum haemorrhage. The random effects model was used for meta-analysis. Risk ratios (RRs) and weighted mean differences (WMDs) were calculated with 95% confidence intervals (CIs). Seven trials with a low risk of bias comparing tranexamic acid vs. placebo with a total of 1760 parturients were included in our systematic review and meta-analysis. Blood loss was significantly lower after tranexamic acid use (WMD -140.29 ml, 95% CI -189.64 to -90.93 ml; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dcc0c9c7c932d6a998a39c541a8edb7a https://doi.org/10.1111/aas.12341 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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