TiNiCuAg shape memory alloy films for biomedical applications

Autor: Chun-Hway Hsueh, Wei-Ting Jhou, Hao-Sen Chiang, Cheng Wang, Seiichiro
Rok vydání: 2018
Předmět:
Zdroj: Journal of Alloys and Compounds. 738:336-344
ISSN: 0925-8388
Popis: TiNi-based shape memory alloys (SMAs) have been largely utilized in stents, orthopedic endo-prostheses and orthodontic implants. While bacterial infection in medical implants is the most common complication, development of antibacterial TiNi-based SMAs is essential. In the present study, a novel antibacterial TiNiCuAg shape memory alloy film (SMAF) was successfully developed by adding silver into TiNiCu matrix. The structural and biological properties of TiNiCuAg SMAF, including crystal structures, phase transformation temperatures, shape memory effect, antibacterial ability and cell cytotoxicity, were systematically investigated. The results showed that the phase transformation temperature gradually decreased and silver started to precipitate with the increasing silver content. The single-stage B2 ↔ B19′ transformation occurred in TiNiCu and Ti 51 Ni 43.5 Cu 4.5 Ag 1 films, while the two-stage B2 ↔ R ↔ B19′ transformation occurred in Ti 49.6 Ni 42 Cu 6.9 Ag 1.5 , Ti 47.4 Ni 41.2 Cu 6.4 Ag 5.6 and Ti 47.7 Ni 41.2 Cu 4.1 Ag 7 films. Moreover, compared to TiNiCu films, TiNiCuAg films performed the better shape memory effect with the increasing silver content. For antibacterial tests, the TiNiCuAg films with the Ag content of 5.6 at.% had the best antibacterial ability against S. aureus and E. coli compared to those of TiNi and TiNiCu films. For cytotoxicity assay, all films maintained good biocompatibility and revealed no cell toxicity for L929 cells. As a result, excellent antibacterial ability and good biocompatibility suggested that TiNiCuAg SMAFs had potential applications for medical implant to avoid bacterial infection.
Databáze: OpenAIRE
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