Effect of Leu- and Met-enkephalins on brain reinforcing systems

Autor: M. I. Titov, Andreev Bv, Yu. D. Ignatov, V. S. Kovalenko
Rok vydání: 1981
Předmět:
Zdroj: Bulletin of Experimental Biology and Medicine. 92:893-895
ISSN: 1573-8221
0007-4888
DOI: 10.1007/bf00836990
Popis: The reinforcing systems of the brain are known to play an important role in the formation of predilection for and dependence on drugs [3]. It has been suggested that the activity of these systems may be modulated by endogenous morphine-like peptides -enkephalins and endorphins [4]. However, information on the direct effect of enkephalins on the reinforcing system is limited and contradictory [i0, 12]. Moreover, there have been virtually no studies of the effect of Leuand Met-enkephalins (LE and ME respectively) on the "punishment" system.
Databáze: OpenAIRE