Pacemaker shifting in the right atrium during vagus nerve stimulation in dogs

Autor:	V. M. Adomonis, F. F. Bukauskas, K. S. Muckus, K. K. Lukosevicius, J. J. Bredikis, A. I. Saudargas
Rok vydání:	1987
Předmět:	business.industry medicine.medical_treatment General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Oculocardiac reflex Peripheral Pathogenesis medicine.anatomical_structure Opioid In vivo Medicine Right atrium Receptor business Vagus nerve stimulation medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 103:433-436
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00842457
Popis:	Dalargin injected subcutaneously at a dose of 10 micrograms/kg decreased 4-5 fold ulcer manifestations in rats with cysteamine-induced duodenal ulcers. Intracerebroventricular dose of 2 micrograms diminished the manifestations to a lesser extent Dalargin only at a dose exceeding 500 micrograms intraperitoneally decreased significantly the in vivo binding of 3H-D-Ala2, D-Leu5-enkephalin with brain opiate receptors. We believe that Dalargin injected peripherally in small doses does not penetrate the blood-brain barrier and that its antiulcer activity is due to the interaction with peripheral opioid receptors. It seems possible that the disturbances in the central/peripheral ratio of the opioid activity plays an important role in the pathogenesis of duodenal peptic ulcer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dc81b72dda44d9eae693bbfbd05ace15 https://doi.org/10.1007/bf00842457 Zobrazit plný text záznamu Full text from SpringerLink