| Autor: |
Yang Lu, Xiujun Zhang, Bo Sun, Tai-Ping Shi, Weiwei Deng, Peng Liu, Jie Zhao, Peng Gao, Ming Li |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Hereditas (Beijing). 30:575-582 |
| ISSN: |
0253-9772 |
| DOI: |
10.3724/sp.j.1005.2008.00575 |
| Popis: |
Activator protein-1(AP-1) is an important transcription factor, and dysregulation of its activity has been associated with many human diseases, including various cancers. A novel human gene AC3-33 (GenBank name: c30rf33, Accession No. FLJ31139), which can suppress PMA and Ionomycin induced activation of AP-1, was identified from 650 human func-tion-known genes by using the high throughput-high content cell-based screening technology. The gene whose full cDNA length is 1391 bp containing 6 exons and 5 introns is located in the human chromosome 3q25.31. The predicted protein encoded by this gene contains 251 amino acids with a theoretical molecular weight of 29 kDa. Expression of the AC3-33 gene is widly found in adrenal glands and cervix. The amino acid sequences of AC3-33 is highly conserved, and has no homology to other known proteins. Subcellular localization studies show that the AC3-33 protein was localized in the cytoplasm. Our preliminary results showed that AC3-33 is an important novel gene related to supress AP-1 activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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