Graphene oxide: A carbocatalyst for the one-pot multicomponent synthesis of highly functionalized tetrahydropyridines
| Autor: | Annah Gupta, Deepika Singh, Ramneet Kaur, Kamal K. Kapoor |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Graphene Organic Chemistry Oxide 010402 general chemistry Key features 01 natural sciences Biochemistry Aldehyde 0104 chemical sciences law.invention Catalysis chemistry.chemical_compound Aniline chemistry law Yield (chemistry) Drug Discovery Organic chemistry Acetonitrile |
| Zdroj: | Tetrahedron Letters. 58:2583-2587 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.05.067 |
| Popis: | A simple, straightforward and efficient methodology is described for the synthesis of polysubstituted tetrahydropyridine via one-pot multicomponent reaction of β-ketoester, aldehyde and aniline in presence of catalytic amount of graphene oxide in acetonitrile. Graphene oxide is a versatile carbocatalyst and this is the first report on its application in a five component reaction. Good yield, usage of readily available starting material, operational simplicity, easy work-up and eco-friendly re-usable catalyst are the key features of this protocol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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