Dapson in Heterocyclic Chemistry, Part II: Antimicrobial and Antitumor Activities of Some Novel Sulfone Biscompounds Containing Biologically Active Thioureido, Carbamothioate, Quinazoline, Imidazolidine, and Thiazole Moieties

Autor:	Mohamed A. A. Radwan, N. M. H. Taha, I. M. I. Faker, M. A. Shehab, N. E. Amin, M. M. Ghorab
Rok vydání:	2008
Předmět:	Catechol Organic Chemistry Antimicrobial Biochemistry Sulfone Inorganic Chemistry chemistry.chemical_compound chemistry Imidazolidine Yield (chemistry) Quinazoline Phenol Organic chemistry Thiazole
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 183:2906-2917
ISSN:	1563-5325 1042-6507
Popis:	The reaction of 4,4′-diisothiocyanato-1,1-diphenylsulfone 2 with aromatic amines and phenol derivatives afforded the corresponding thioureio derivatives 3–9 , respectively. Also, the reaction of 2 with catechol gave the corresponding carbamothioate derivative 11. Quinazoline derivatives 14 and 15 were obtained in good yield via reaction of 2 with anthranlic acid derivatives. Imidazolidine biscompounds 16 and 17 were readily synthesized from the reaction of 2 with N-(4-substituted-phenyl)cyanothioformanilides. The structure of the products was confirmed from elemental analysis as well as spectral data. Most of the synthesized compounds showed remarkable antimicrobial activity compared with chloramphenicol and Grisofluvine as positive controls. Compound 6 was almost as active an antitumor agent as the reference drug Doxorubicin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dc72c49c059a1d65b9ac8c98906976f0 https://doi.org/10.1080/10426500802505424 Zobrazit plný text záznamu