Experimental research on the anti-cancer immunomodulative effect of the polysocoharibe-peptide of coriolus versicolor
| Autor: | Xiaoyu Li, Junmo Wang, Qingyao Yang, Ruiting Chen, Yujuan Hu, Liangzhong Xu, Jinxu Zhou |
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| Rok vydání: | 1989 |
| Předmět: |
Drug
chemistry.chemical_classification Cancer Research Chemotherapy media_common.quotation_subject medicine.medical_treatment Cancer Hemolysin Peptide Biology Pharmacology medicine.disease eye diseases Ehrlich ascites carcinoma Microbiology Oncology chemistry Cell culture medicine Nucleic acid media_common |
| Zdroj: | Chinese Journal of Cancer Research. 1:7-12 |
| ISSN: | 1993-0631 1000-9604 |
| DOI: | 10.1007/bf02684809 |
| Popis: | Polysocoharibe-peptide of Coriolus Versicolor (PSP) is a new anti-cancer immunomodulative drug. The present paper reports on the experimental research done with this drug. It was found that PSP had the ability to recover hemolysin HC50, to increase the weight of the thymus, and increase the alexin of serum C3 and the IgG content of tumor bearing mice. PSP also significantly raised the phagocytic activity of macrophages in normal mice. PSP had a significant inhibitory effect on P388 and S180 cells. At the concentration of 1 mg/ml, PSP inhibited the proliferating activity of some human tumor cell lines, such as SGC 7901, SPC, SLY and Mei. It had a direct toxic effect on SPC cells. PSP significantly inhibited the synthesis of nucleic acids of Ehrlich ascites carcinoma cells. In addition, PSP was antagonistic to the side effects of chemotherapy and radiotherapy. |
| Databáze: | OpenAIRE |
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