Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib

Autor:	Andrew Dalgleish, Keith R. Mulholland, Andrew D. Campbell, David Dave, Hannah Askey, Zhaoshan Cui, Gareth AstraZeneca R D Charnwood Ensor, Shenghua Wang, Peter R. Hamilton, Simone Tomasi, Mark A. Graham, Claire Heffernan, Lai Chan, Pengpeng Liu, Emma Randles, Martin F. Jones, Michael Popadynec, Dajiang Jing, Cooper Katie Grace, Mohammed Pervez, Maria Rita Galan Espinosa, Jackson Lucinda Victoria
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Pyrimidine chemistry 010405 organic chemistry Cyclopropanation Morpholine Organic Chemistry Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Organic Process Research & Development. 25:43-56
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00482
Popis:	Ceralasertib is currently being evaluated in multiple phase I/II clinical trials for the treatment of cancer. Its structure, comprising a pyrimidine core decorated with a chiral morpholine, a cyclo...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dc66085aa358221a9fd2060b7defbf4b https://doi.org/10.1021/acs.oprd.0c00482 Zobrazit plný text záznamu