Utility of Ki67 immunostaining in the grading of pineal parenchymal tumours: a multicentre study
| Autor: | Marie Bernadette Delisle, Michel Peoc'h, Annie Laquerrière, François Fauchon, Jacques Champier, M.-H. Aubriot Lorton, Catherine Miquel, I. Quintin Roué, Jean-François Michiels, Françoise Chapon, Marc Polivka, Michelle Fèvre-Montange, Dominique Figarella-Branger, Alexandru Szathmari, Anne Jouvet, Alexandre Vasiljevic, D. Frappaz, A. Coulon |
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| Rok vydání: | 2012 |
| Předmět: |
Pineoblastoma
Neoplasm Grading Pathology medicine.medical_specialty Histology Mitotic index business.industry Pineocytoma medicine.disease Pathology and Forensic Medicine Neurology Physiology (medical) medicine Immunohistochemistry Pinealoma Neurology (clinical) business Grading (tumors) Immunostaining |
| Zdroj: | Neuropathology and Applied Neurobiology. 38:87-94 |
| ISSN: | 0305-1846 |
| DOI: | 10.1111/j.1365-2990.2011.01202.x |
| Popis: | M. Fevre-Montange, A. Vasiljevic, D. Frappaz, J. Champier, A. Szathmari, M.-H. Aubriot Lorton, F. Chapon, A. Coulon, I. Quintin Roue, M.-B. Delisle, D. Figarella-Branger, A. Laquerriere, C. Miquel, J.-F. Michiels, M. Peoch, M. Polivka, F. Fauchon and A. Jouvet (2012) Neuropathology and Applied Neurobiology38, 87–94 Utility of Ki67 immunostaining in the grading of pineal parenchymal tumours: a multicentre study Aims: Pineal parenchymal tumours (PPTs) are rare neoplasms that are divided into pineocytoma (PC), pineoblastoma (PB) and PPT of intermediate differentiation (PPTID). Factors affecting the survival of patients with PPTs are morphological subtype and histological grading according to mitotic index and neurofilament immunostaining. Grading criteria to distinguish PPTIDs are difficult to define, particularly when using small specimens. The Ki67 labelling index (LI) might be helpful in distinguishing between grade II and III PPTIDs. Our study was performed to assess the predictive value of the Ki67 LI in a large cooperative series of PPTs and to evaluate whether inclusion of this data would improve and refine the World Health Organization classification. Methods: A retrospective analysis of 33 PPTs was performed. The histological features of the tumours were reviewed and Ki67 LI scoring was evaluated by immunohistochemistry. Data were correlated with the patients' survival. Results: The mean Ki67 LI was significantly different for tumour grades (0 in PC, 5.2 ± 0.4 in PPTID grade II, 11.2 ± 2.0 in PPTID grade III, 36.4 ± 6.2 in PB; P |
| Databáze: | OpenAIRE |
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