| Autor: |
Kenneth K. Y. Wong, Anson H. L. Tang, Kevin K. Tsia, Kelvin C. M. Lee, Dickson M. D. Siu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
High-Speed Biomedical Imaging and Spectroscopy IV. |
| Popis: |
Continuing development of image-based bioassay is mainly hampered by the lack of throughput to systematically screen a large cell/tissue population under extensive experimental conditions; and the overwhelming reliance on biochemical markers, which are not always effective, especially when there is poor prior knowledge of the markers. Here we demonstrate ultralarge-scale, high-resolution “on-the-fly” quantitative phase imaging (QPI) of single-cells and whole-tissue-slide on a spinning-disk assay platform at an imaging rate of at least 100-times faster than current assays – mitigating the imaging throughput limitation hindered by the fundamental space-bandwidth-product limit of classical optical imaging. The concept takes advantage of the high-speed spinning motion, which naturally provides imaging at an ultrafast rate ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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