Reduced capillary permeability and capillary density in the skin of GH-deficient adults: improvement after 12 months GH replacement
| Autor: | John A. M. Beentjes, AJ Smit, E. Bosma, Robin P. F. Dullaart, W. D. Reitsma, P. H. N. Oomen |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism Vascular permeability medicine.disease Growth hormone deficiency chemistry.chemical_compound Light intensity Endocrinology Blood pressure chemistry Interquartile range Internal medicine Extracellular fluid medicine Fluorescein Complication business |
| Zdroj: | Clinical Endocrinology. 56:519-524 |
| ISSN: | 0300-0664 |
| Popis: | OBJECTIVE Several lines of evidence suggest that the GH-IGF-1 axis affects capillary permeability and angiogenesis. We evaluated skin capillary permeability and capillary density in GH-deficient adults, before and after GH replacement therapy. PATIENTS Seven normotensive, nondiabetic GH-deficient adults (two women) were matched with 14 control subjects. MEASUREMENTS Large-window videodensitometry with sodium fluorescein was performed in all subjects. Capillary permeability was expressed as the average relative light intensity over the first 7 min after the appearance of fluorescein in the skin capillaries; l(av)(7). Skin capillary density was determined by counting the visualized capillaries and was expressed as n/mm(2). The GH-deficient patients were restudied after 12 months of GH replacement therapy (2 U/day). RESULTS Both capillary permeability and capillary density were lower in untreated GH-deficient patients than in control subjects (median, interquartile range): I-av(7) in GH-deficient patients 47.1 (45.1-52-2)% vs. 57.5 (50.5-64.8)% in controls, P |
| Databáze: | OpenAIRE |
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