Sequence analysis of Epstein–Barr virus BALF2 gene in associated tumors and healthy individuals from southern and northern China
| Autor: | Cai-xia Yu, Wen Liu, Meng-he Zhao, Hua Xiao, Yun Wang, Bing Luo |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Future Virology. 17:617-626 |
| ISSN: | 1746-0808 1746-0794 |
| DOI: | 10.2217/fvl-2021-0177 |
| Popis: | Aim: The purpose of this study is to investigate the polymorphism and distribution characteristics of BALF2 gene in Epstein–Barr virus (EBV)-associated tumors (gastric cancer, nasopharyngeal carcinoma and lymphoma). Materials & methods: DNA sequences of 349 EBV-related samples were analyzed by nested PCR combined with DNA sequencing. Results: According to the phylogenetic tree, BALF2 was divided into six genotypes ( BALF2-A–F). Statistically, the incidence of BALF2-E in nasopharyngeal carcinoma was higher than that in healthy people, and the incidence of BALF2-E in nasopharyngeal carcinoma in South China was higher than that in North China (p = 0.001). Conclusion: BALF2 variants in EBV-associated samples are not only tumor-specific, but also differ between northern and southern regions. |
| Databáze: | OpenAIRE |
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