The role of systemic steroids and phototherapy in the treatment of stable vitiligo: a randomized controlled trial
| Autor: | Medhat El Mofty, Heba M. Mashaly, Iman Saney, Doaa Mahgoub, Samia Essmat, Rana Helal, Randa Youssef, Akmal Saad, Olfat G. Shaker, Amira El Tawdy, Sherine Sobeih, Sherine Ossama |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
chemical and pharmacologic phenomena Dermatology Vitiligo complex mixtures Group A Gastroenterology Group B law.invention Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine business.industry Multifactorial disease General Medicine bacterial infections and mycoses medicine.disease Therapeutic modalities Surgery 030220 oncology & carcinogenesis bacteria business After treatment |
| Zdroj: | Dermatologic Therapy. 29:406-412 |
| ISSN: | 1396-0296 |
| DOI: | 10.1111/dth.12384 |
| Popis: | Pathogenesis of vitiligo is believed to be multifactorial disease with a wide variety of therapeutic modalities. The aim of this work is to assess the efficacy of oral mini-pulse steroids (OMP) plus Nb-U.V.B in comparison to OMP alone and Nb-U.V.B alone in treating stable vitiligo. A prospective randomized controlled study including 45 patients categorized into three groups receiving therapy for 3 months; Group A received Nb-U.V.B plus OMP, Group B received OMP alone while Group C received Nb-U.V.B alone. Clinical assessment and PCR evaluation of bFGF, ICAM1, and ELISA for AMA were done. Patients receiving Nb-U.V.B plus OMP and using Nb-U.V.B alone gave statistically significant clinical response than those treated with OMP alone. Statistically significant rise of BFGF was noticed after treatment with Nb-U.V.B plus OMP and with Nb-U.V.B alone. Patients treated with OMP alone and with Nb-U.V.B alone showed statistically significant drop of ICAM-1 after therapy. NB-U.V.B plus OMP and Nb-U.V.B alone were found to be clinically superior over OMP alone in treating stable vitiligo patients, hence suggesting that adding OMP to Nb-U.V.B can maintain clinical and laboratory success for a longer period of time and with less relapse. |
| Databáze: | OpenAIRE |
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