Reverse Docking on Five Original PPO Structures: Plant, Bacterial, and Human
| Autor: | T. Lakhlifi, M. Bouachrine, O. Abdessadak, H. Hajji, S. Mehanned, M. Aziz Ajana |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| DOI: | 10.48317/imist.prsm/morjchem-v10i3.33065 |
| Popis: | Protoporphyrinogen oxidase has known remarkable interest in biochemical studies, it is considered a perfect target for the development of new herbicides. PPO herbicides have been developed for more than forty years, and research on this enzyme remains until today, to find new more effective herbicides. In this work, we investigated the inhibitory activity of a compound derived from N-phenylphthalimide with the highest inhibitory activity among a series of 29 molecules, on five PPO structures from various origins, including Plant origin, bacterial, and human, we have based on Reverse Docking, to know the affinity between the inhibitor and the five targets, and the different ligand-receptor interactions. As well as Molecular Dynamics. Interesting results have been obtained, which may help us to discover new targets concerning herbicides. Moroccan Journal of Chemistry, مجلد 10, عدد 3 (2022): in progress |
| Databáze: | OpenAIRE |
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