ChemInform Abstract: Negishi Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents

Autor:	Matthias A. Schade, Carmen Munoz Hernandez, Georg Manolikakes, Paul Knochel, Herbert Mayr
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Hydrogen Negishi coupling Aryl chemistry.chemical_element Halide General Medicine Zinc Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Reagent Alkyl
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200845044
Popis:	A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated halides bearing an acidic NH or OH function, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups.
Databáze:	OpenAIRE
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