Binding biomolecules with designed, hydrogen-bonding receptors

Autor:	Alisher B. Khasanov, Thomas W. Bell, Nicholas M. Hext
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Analyte Arginine Chromogenic Hydrogen bond General Chemical Engineering Biomolecule General Chemistry Combinatorial chemistry Crystallography chemistry.chemical_compound chemistry Reagent Urea Receptor
Zdroj:	Pure and Applied Chemistry. 70:2371-2377
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac199870122371
Popis:	An approach to the design of artificial receptors is described involving the fusion of several sixmembered rings, preorganizing nitrogen and oxygen hydrogen bonding sites. A hexagonal lattice chemosensor extracts the blood metabolite creatinine into water and acts as a chromogenic reagent for this clinical analyte. Another receptor binds urea via six hydrogen bonds, forming a complex that is stable even in DMSO. A water-soluble receptor has now been synthesized that recognizes the guanidinium sidechain of arginine in aqueous media.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dc21c01925d9e6e7a16d5adcf86c3fb9 https://doi.org/10.1351/pac199870122371 Zobrazit plný text záznamu