Synthesis and Binding Affinity to Human ? and ? Estrogen Receptors of Various 7-Hydroxycoumarins Substituted at 4- and 3,4-Positions
| Autor: | Serge Kirkiacharian, Evelyne Cerede, Anh Tuan Lormier, Francoise Bouchoux, Henri Chidiack |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | ChemInform. 36 |
| ISSN: | 1522-2667 0931-7597 |
| Popis: | The study of the relative binding affinity (RBA) to the human α and β estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERα and ERβ. The 4-(4-hydroxyphenyl)-7-hydroxycoumarin shows a weak RBA to ERβ and 3,4-diphenyl-7-hydroxycoumarin presents a stronger RBA to ERα than ERβ. |
| Databáze: | OpenAIRE |
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