Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease

Autor: Corey A. Siegel, Dermot P B Mc Govern, Stephan R. Targan, Karen Lasch, Janine Bilsborough, Jonathan Braun, Carol J. Landers, Marla Dubinsky, Thierry Dervieux, Fred Princen, Ninfa Candela, Lori S. Siegel
Rok vydání: 2021
Předmět:
Zdroj: Crohn's & Colitis 360. 3
ISSN: 2631-827X
DOI: 10.1093/crocol/otab074
Popis: Background Patients with Crohn’s disease (CD) are at risk of complications. Performance characteristics of a decision support tool assessing the risk of CD complications were evaluated. Methods CDPATH (formerly called the Personalized Risk and Outcome Prediction Tool [PROSPECT]) was calibrated and validated in 2 cohorts. Tool prediction of disease characteristics was assessed using Cox regression and Harrell’s C-statistic. Results All associations of CD complications and CDPATH components were significant except perianal location. There was a significant association between individualized risk assessment scores and CD complications in both cohorts. Conclusion CDPATH is validated as a clinical decision support tool for assessing the risk of CD complications.
Databáze: OpenAIRE