A CASE OF SECONDARY GASTROINTESTINAL AMYLOIDOSIS WITH SMALL BOWEL PERFORATION

Autor: Yuji Takagi, Yoshinori Hashimoto, Daikichi Okada, Fusao Kubota, Toshio Takada, Takafumi Yamada, Teruhisa Shimizu, Isao Shimokawa, Masumi Ifuku
Rok vydání: 1988
Předmět:
Zdroj: The journal of the Japanese Practical Surgeon Society. 49:527-531
ISSN: 0386-9776
DOI: 10.3919/ringe1963.49.527
Popis: We encountered a case of small bowel perforation due to gastrointestinal amyloidosis secondary to rheumatoid arthritis. The patient was a 56-year-old woman who has been receiving treatment for rheumatoid arthritis for about 16 years, a nd in whom nausea, vomiting and loss of appetite appeared. Emergency operation for perforative peritonitis which appeared as a complication during scrupulous examination for suspected gastrointestinal amyloidosis revealed a perforation of about 2 mm in the small intestine 1.5 m from Treitz' ligament. About 1m of the small intestine, including the site, was resected. Tissue specimens were stained with HE and Congo red, and observed by polarizing microscopy. Remarkable deposits of amyloid were present in the submucosal intestitial tissues and perivascular tissues, by which the patient was diagnosed as having small bowel perforation due to gastrointestinal amyloidosis. Since the patient was treated surgically too late, she died 6 hours after the surgery. We considered that indications for surgical treatment for amyloidosis were limited.
Databáze: OpenAIRE