Microwave Assisted Synthesis and Antibacterial Evaluation of 1, 3, 4-Thiadiazole Derivatives

Autor:	Sheeba Jasmin Ts, Jayalakshmi P M, Manu Jose
Rok vydání:	2021
Předmět:	Chemistry medicine.drug_class 1 3 4 thiadiazole derivatives medicine Pharmacology (medical) Agar well diffusion Antibacterial activity Microwave method Pharmacology Toxicology and Pharmaceutics (miscellaneous) Microwave assisted Anti-inflammatory Nuclear chemistry
Zdroj:	Research Journal of Pharmacy and Technology. :5293-5296
ISSN:	0974-360X 0974-3618
Popis:	1,3,4-Thiadiazole is an important heterocyclic moiety, forms an integral core structural component of different categories of drugs such as antimicrobial, antitubercular, anti-inflammatory, antiepileptic, antiviral, antineoplastics, and analgesic agents. It is a key moiety in current discovery and designing of new drugs. The compounds were synthesised by both conventional method and microwave method. The targeted derivatives can be synthesised in a shorter time under microwave condition than under conventional reaction condition. Their structures were confirmed by FT-IR and NMR Spectroscopy. Antibacterial property of two synthesised analogs were evaluated by Agar well diffusion method against Escherichia coli and Staphylococcus aureus. The results of antibacterial activity showed that both the compounds were active against Staphylococcus aureus and inactive against Escherichia coli. Results of invitro studies showed that modifications in SB-2-PHB and SB-8-PHB will make it as a promising lead molecule for further research.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dc055a5f2d6237e762d79a76811d6187 https://doi.org/10.52711/0974-360x.2021.00923 Zobrazit plný text záznamu