Preparation of the amphiphilic copolymer of poly(γ-benzyl L-glutamate)-g-poly(ethylene glycol) with different grafting ratio

Autor:	Xiumiao Zhou, Jianhong Yi, Biaobing Wang, Guosheng Hu
Rok vydání:	2010
Předmět:	Polymers and Plastics Chemistry Grafting Micelle Catalysis chemistry.chemical_compound L glutamate Transmission electron microscopy Polymer chemistry PEG ratio Materials Chemistry Ceramics and Composites Ethylene glycol Amphiphilic copolymer
Zdroj:	Polymer Science Series B. 52:35-40
ISSN:	1555-6123 1560-0904
DOI:	10.1134/s1560090410010057
Popis:	Poly(γ-benzyl L-glutamate)- g-poly(ethylene glycol) (PBLG-g- PEG) with different grafting ratio was prepared using P-toluenesulfonic acid as catalyst. The effect of the molecular weight of mono- methyl oligo(ethylene glycol), the molar feed ratio and reaction time on the grafting ratio was investigated. The micelles of PBLG-g-PEG were prepared by the dialysis method in deionized water. Transmission electron microscopy and dynamic light scatter studies showed that the micelles exhibited spherical morphologies and the diameter of the micelles was in the range of 50–200 nm. Clonazepam was loaded onto the core part of the micelles and drug-loading content and rele ase rate were dependent on the grafting ratio.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dc04d08c5135d7de94556d5ab35f0600 https://doi.org/10.1134/s1560090410010057 Zobrazit plný text záznamu Full text from SpringerLink