| Autor: |
Dhanshri R. Mali, Anjali Popat Ghuhe, Nikita Murlidhar Khairnar, Sakshi Milind Kothawade |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Asian Journal of Organic & Medicinal Chemistry. 7:280-286 |
| ISSN: |
2456-8937 |
| DOI: |
10.14233/ajomc.2022.ajomc-p402 |
| Popis: |
A series of novel 2-aminothiazole derivatives were synthesized by microwave assisted method as a green chemistry approach and characterized by spectral techniques and elemental analysis. The antioxidant potential of the derivatives was determined by using molecular docking against two different oxidoreductase protein (PDB: 2CDU and 3NM8). Compounds 3a and 3d show the stronger binding affinity to the target protein. The synthesized drug was pharmacologically evaluated for the antioxidant activity using ascorbic acid as a reference drug, where compound 3a showed the highest inhibition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
