The role of exogenous peptides in restoration of full immune response under secondary immunodeficiency

Autor: O.F. Tatskyy, A.I. Kurchenko, Llc Spirica, Kyiv, Ukraine, H.P. Potebnya, V.A. Benyuk, O.S. Neymark, V.L. Kobys
Rok vydání: 2017
Předmět:
Zdroj: HEALTH OF WOMAN. :89-97
ISSN: 2307-5074
1992-5921
DOI: 10.15574/hw.2017.117.89
Popis: The objective: defining the role of immunomodulation with the use of exogenous peptides MHP (Camelyn-Bio) on the effectiveness of treatment of cervical dysplasia I-II that was caused by mixed chlamydia and human papillomavirus infection. Patients and methods. In accordance with the objectives of the study we selected and randomized 72 patients with dysplasia (paplomavirus-chlamydial etiology). Women were divided into two groups: basic (n=36) and control (n=36) matched by age, symptoms and duration of the process. The main conventional treatment group received Camelyn-Bio capsules at a dose of 1 capsule (0.19 g) 3 times a day 30 days from starting treatment. Results. The result of the reduction in viral load lower than a clinically significant threshold (3 lg) was achieved in 70% of patients in control group and 77.8% in the main group. Therefore, adequate complex therapy taking into account the role of exogenous peptides reduces the activity of HPV, promotes its elimination, reduces the frequency of relapses. The effectiveness of combined therapy of mild cervical dysplasia with the use of Camelyn-Bio was 88.9%. In the group of patients receiving standard therapy, the efficacy was 83.4%. Conclusion. Now to resolve vital clinical tasks a practitioner has an innovative agent Camelyn-Bio, which, in particular, speeds up the elimination of HPV in women of childbearing age. The inclusion of Camelyn-Bio in the traditional scheme of treatment of cervical dysplasia is justified etiopatogeneticaly and allows to harmonize the immune homeostasis of patients and allows to increase the effectiveness of treatment. Key words: exogenous peptides, T-lymphocytes, macrophages, interleukins, immune homeostasis, human papillomavirus, dysplasia, treatment, efficacy.
Databáze: OpenAIRE
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