Evaluation of Regulatory T cells in Obese Asthmatic Children
| Autor: | Mohamed M Zedan, Nanees Salem, Magdy Zedan, Layla M. Saleh, Hoda Nasser Abbass |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry FOXP3 hemic and immune systems chemical and pharmacologic phenomena Eosinophil medicine.disease Gastroenterology Pulmonary function testing medicine.anatomical_structure Immune system Internal medicine medicine IL-2 receptor business Interleukin-7 receptor Body mass index Asthma |
| Zdroj: | The Egyptian Journal of Pediatric Allergy and Immunology. 18:79-85 |
| ISSN: | 2314-8934 |
| Popis: | Background: Asthma is an airway inflammatory disorder with functional and structural changes. Regulatory T (T reg) cells are important in controlling immune responses. The study was aimed to investigate the frequency of Treg cells in obese asthmatic children, in comparison to non-obese asthmatics and healthy matched controls .Methods: In addition to anthropometric and body mass index (BMI) assessment, peripheral blood samples from healthy control subjects (n = 30) and asthmatic obese (n=30) and asthmatic non-obese children (n=30) were examined for serum IgE, eosinophils counts, and flowcytometric measurement of CD4+CD25+CD127 low/neg- T cells. Pulmonary function testing was performed for asthmatic children . Results: Obese asthmatics showed significantly higher levels of serum IgE and CD4+CD25+CD127 low/neg- T cells as compared to healthy controls (p |
| Databáze: | OpenAIRE |
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