| Popis: |
Nanomedicines are widely used as possible therapeutics and diagnostics for wide variety of diseases. It have been used for successful delivery of hydrophilic and hydrophobic small molecules drugs, and biomacromolecules, such as enzymes, recombinant proteins, peptides, hormones, monoclonal antibodies and also used for the delivery of nucleic acids of different sizes and structures.Gold nanoparticles possess promising ameliorative effects due to their distinctive properties such as high surface reactivity, biocompatibility, flexibility in functionalization and a broad range of delivery targets. This study was designed to investigate the protective effect of green synthesised gold nanoparticles (AuNPs) using aqueous bark extract of Terminaliaarjunaon acetaminophen induced immunotoxicityin the experimental rat model.Group1- Control group; Group 2- Acetaminophen administered intraperitoneally at concentration of 500mg /kg of body weight for 14 days; Group 3- Co-administration of Terminaliaarjuna aqueous bark extract (175µg/kg/day) along with acetaminophen (500mg/kg/day) treatment for 14 days; Group 4- Co-administration of AuNPs (175µg/kg/day) along with acetaminophen treatment (500mg/kg/day) intraperitoneally for 14 days. After 14 days all animals were sacrificed for the immunological analysis.Immunological analysis revealed that there was significant decrease in the IL-10 level with acetaminophen treatment but marked increase in the KIM-1, Cystatin C, TNF-alpha and, IL-18 level.After co-administration with AuNPs along with acetaminophen showed effective significant recovery in theexpression of inflammatory biomarkers. Hence, the results highlighted on the protective effectsAuNPs against acetaminophen inducedimmunotoxity. |
