Autor:	Klekamp J
Rok vydání:	2002
Předmět:	medicine.medical_specialty Pathology Neurology Cord business.industry medicine.disease Spinal cord Central nervous system disease medicine.anatomical_structure Cerebrospinal fluid Extracellular fluid medicine Surgery Neurology (clinical) Neurosurgery business Neuroscience Syringomyelia
Zdroj:	Acta Neurochirurgica. 144:649-664
ISSN:	0001-6268
DOI:	10.1007/s00701-002-0944-3
Popis:	Various ideas and hypotheses have been brought forward to explain the development of syringomyelia in the past two centuries. None of them offers a sufficient basis to serve as a concept for the treatment of all affected patients. Apart from a discussion of the different hypotheses this paper proposes a new pathophysiological concept based on clinical, experimental and literature studies. Syringomyelia is understood as a state of chronic interstitial edema of the spinal cord due to accumulation of extracellular fluid (ECF). This accumulation is caused by a cascade of events starting with obstruction of cerebrospinal fluid (CSF) flow and/or spinal cord tethering which ultimately alter ECF flow and increase ECF volume. Treatment should be targeted against the pathological process which causes CSF flow obstruction and cord tethering to inhibit this pathophysiological process at a decisive point.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dbf2d289e2fcd5b5549f15edc66454e7 https://doi.org/10.1007/s00701-002-0944-3 Zobrazit plný text záznamu Full text from SpringerLink