ChemInform Abstract: Synthesis and Properties of the Derivatives of 2-Alkylthio-4-oxo-3,4-(and -1,4)-dihydropyrido(2,3-d)pyrimidine-5-(and -6)-carboxylic Acids

Autor:	Zawisza T, Bartoszko-Malik A, Sladowska H
Rok vydání:	1990
Předmět:	chemistry.chemical_compound chemistry Injury control Pyrimidine Accident prevention Poison control General Medicine Carboxylate Alkylation Medicinal chemistry
Zdroj:	ChemInform. 21
ISSN:	0931-7597
DOI:	10.1002/chin.199037218
Popis:	Condensation of diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (I) with the corresponding isothiocyanates afforded derivatives of ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine-5-carboxylate (V-VII). Alkylation of (V), (VI) and (XI) gave the corresponding derivatives of ethyl 2-alkylthio-4-oxo-3,4-(and 1,4)-dihydropyrido[2,3-d]pyrimidine-5- and -6- carboxylate [(XII-XVI), (XX-XXII)]. Some of the obtained compounds were active pharmacologically. Language: en
Databáze:	OpenAIRE
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