Familial Early-Onset Type 2 Diabetes in Chinese Patients
| Autor: | Gary T.C. Ko, Julian A.J.H. Critchley, S. C. Lee, Ian R. Mackay, June K.Y. Li, Maggie C.Y. Ng, Clive S. Cockram, Anthony H. Barnett, Yasmeen Hashim, Juliana C.N. Chan, Wing-Yee So |
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| Rok vydání: | 2001 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty business.industry Glucokinase Endocrinology Diabetes and Metabolism Amylin Type 2 diabetes Gene mutation medicine.disease Obesity Diabetes mellitus genetics Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria medicine.symptom business |
| Zdroj: | Diabetes Care. 24:663-671 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE—We examined the prevalence of different forms of diabetes in Hong Kong Chinese patients with familial early-onset type 2 diabetes and compared their clinical features with patients with familial late-onset type 2 diabetes. RESEARCH DESIGN AND METHODS—A total of 145 young patients with early-onset diabetes (age and age at diagnosis ≤40 years) and a family history of diabetes were studied. They were screened for mutations in the genes encoding glucokinase, hepatocyte nuclear factor (HNF)-4α, and HNF-1α. The mitochondrial DNA A→G at nucleotide 3243 (mt3243) and amylin S20G mutations were studied, and antibodies to GAD (anti-GADs) were also examined. RESULTS—The prevalence of putative diabetogenic gene mutations and autoimmune markers were 4% for glucokinase, 0% for HNF-4α, 5% for HNF-1α, 3% for mt3243, 2% for amylin S20G, and 4% for anti-GAD. Compared with late-onset patients, the patients with early-onset diabetes had a higher prevalence of a parental history of diabetes and were generally more obese. When classified by obesity indexes (BMI and waist circumference), the obese patients, especially those with early-onset diabetes, had a clustering of cardiovascular risk factors and increased rates of retinopathy and albuminuria. CONCLUSIONS—Genetic factors (up to 14%) and obesity (55%) play more significant roles than autoimmunity (4%) in familial type 2 diabetes in young Chinese patients. The significance of obesity-related genes and other gene-gene and gene-environment interactions in these young patients remains to be determined. |
| Databáze: | OpenAIRE |
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