| Autor: |
Jaap J. Beintema, Adriana Furiat, Antonella Carsana, Heleen J. Breukelman |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Ribonucleases ISBN: 9780125889452 |
| DOI: |
10.1016/b978-012588945-2/50009-1 |
| Popis: |
Publisher Summary This chapter covers evolution of ribonuclease A superfamily. The pyrimidine-specific ribonuclease A superfamily constitutes a group of homologous proteins with well-characterized and sequenced members isolated from many mammalian, avian, reptilian, and amphibian sources. No representatives have been found in fishes or nonvertebrate taxa. It is speculated that there exists a protein in these more distantly related taxa that has some sequence similarity with members of the ribonuclease A superfamily or has a similar fold of the polypeptide chain without demonstrable ribonuclease activity. Distantly related members of the ribonuclease A superfamily differ at more than 50% of the amino acid positions. The nomenclature of members of the ribonuclease A superfamily is rather chaotic, especially that of paralogous ribonucleases identified in the same species. This chapter discusses about ribonuclease superfamily. It explains concepts related to rodent ribonucleases. It also describes structure, evolution, and enzymatic properties of ribonuclease superfamily. An overview of mammalian ribonucleases 2 is also presented in this chapter. The chapter also elaborates in detail about primate ribonucleases and artiodactyl ribonucleases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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