Heteroannulation of 4-oxo-4H-1-benzopyrans (chromones) via the conjugate addition of haloalkanols in the presence of base

Autor:	Roy Hayes, Peter J. Cremins, Timothy W. Wallace
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Ketone Organic Chemistry Alkylation Biochemistry Medicinal chemistry Potassium carbonate chemistry.chemical_compound chemistry Intramolecular force Drug Discovery Chromone Acetone Organic chemistry Benzopyrans Conjugate
Zdroj:	Tetrahedron. 47:9431-9438
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)80889-9
Popis:	Chromones (4-oxo-4H-1-benzopyrans) bearing electron-withdrawing substituents at C-3 react with 2-haloethanols and potassium carbonate in acetone to produce tetrahydrofuro[2,3-b][1]benzopyran-4-ones, the heteroannulation proceeding via the conjugate addition of the haloethanol to the chromone, followed by intramolecular alkylation. Under the conditions of the reaction, the products derived from chromone-3-carbaldehydes undergo in situ deformylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dbe764c4434c47bb1c0a7554652874ae https://doi.org/10.1016/s0040-4020(01)80889-9 Zobrazit plný text záznamu