Asymmetric Bioreduction of an Allylic Ketosulfone to its Corresponding (R)-Alcohol

Autor:	Sarah Stahl, Xin Wang, Richard D. Tillyer, Philippe Dagneau, Paul D. O’Shea, Anthony O. King, Michel Chartrain, Randolph Greasham
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Allylic rearrangement Ketone Stereochemistry Alcohol Biochemistry Catalysis Yeast chemistry.chemical_compound chemistry Biocatalysis Organic chemistry Fermentation Enantiomer Enantiomeric excess Biotechnology
Zdroj:	Biocatalysis and Biotransformation. 18:471-477
ISSN:	1029-2446 1024-2422
DOI:	10.3109/10242420009015264
Popis:	The screening of 144 microbial strains yielded several suitable biocatalysts for the asymmetric bioreduction of an allylic ketosulfone to its corresponding (R)-alcohol. The production of the desired enantiomer with elevated optical purity (ee > 90%) was achieved by the yeast strain Candida magnoliae MY 1785. The enantiocomplementary chiral reduction, the production of the (5)-alcohol, was also achieved when employing other microbial strains. The production of preparative amounts (about 2.5 g) of the (R)-enantiomer with elevated optical purity (ee > 90%) was completed when employing the yeast strain Candida magnoliae.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dbe6f79d7b878c2f8061566a1425c111 https://doi.org/10.3109/10242420009015264 Zobrazit plný text záznamu