| Popis: |
Cancer is certainly among the most traumatic diseases with the addition of more than ten million new cases every year. The usage of chemotherapy agents is admissible as an effective treatment method despite of their well-known irreversible side effects to vital tissues and organs. In spite of the advancement in nanotechnology, which allows us to develop new generation nanocarriers, the human body is a very complex system and possesses many challenges such as biocompatibility, biodistribution, side effects, biological barriers, and so forth against drug delivery systems. In this regard, a perfectly designed nanocarrier should contain multifunctional properties to overcome these obstacles. Additionally, a smart nanocarrier system should deliver the drug to the specific place at the right dosage and time. Therefore, to develop this kind of smart therapeutic system, the desired properties such as imaging, diagnosis, and targeted delivery might be combined into a single system by fabrication of a hybrid nanocarrier. On this account, the hybrid nanocarriers have a promising potential to find application areas in the future of nanomedicine. In this chapter, we will discuss the new generation and promising hybrid nanocarriers based on noble metal, porous silica, polymer, and core–shell therapeutics, which exhibit active targeting, triggered release of cargo, and imaging capability for in vivo studies. |
