Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives

Autor:	N. S. Makara, S. F. Gabdrakhmanova, T. A. Sapozhnikova, R. Yu. Khisamutdinova, A. R. Uzbekov, F. S. Zarudii, G. F. Vafina
Rok vydání:	2017
Předmět:	Pharmacology Sulfonyl chemistry.chemical_classification Choleretic 010405 organic chemistry Thiazolidine 01 natural sciences Medicinal chemistry 0104 chemical sciences Transaminase chemistry.chemical_compound Enzyme Blood serum chemistry Drug Discovery Levopimaric acid Acute hepatitis
Zdroj:	Pharmaceutical Chemistry Journal. 51:348-350
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-017-1612-5
Popis:	The hepatoprotective and choleretic activities of three levopimaric acid derivatives were studied experimentally using a CCl4-induced acute hepatitis model in rats. It was established that all investigated levopimaric acid derivatives tended to increase bile secretion whereas (5R,9R,13S,18S)-20-isopropyl-5,9-dimethyl-17-{[(4-methylphenyl)sulfonyl]imino}-14-oxopentacyclo[10.6.2.01, 10.04, 9.013, 18]eicosa-15,19-diene-5-carboxylic acid (I) and dimethyl (4bS,8R)-2-isopropyl-3′-4b,8-trimethyl-2′,4′-dioxo-4,4a,4b,5,6,7,8,8a,9,10-decahydro-3H-spiro[3,10a-ethanophenanthrene-11,5′-[1,3]thiazolidine]-8,12-dicarboxylate (II) reduced transaminase enzyme levels in blood serum.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dbe22637825ebef7afc8c3800c1e683d https://doi.org/10.1007/s11094-017-1612-5 Zobrazit plný text záznamu Plný text ve formátu PDF