AB0719 CLINICAL FEATURES OF PATIENTS WITH ANKYLOSING SPONDYLITIS AND SECONDARY AA-AMYLOIDOSIS
| Autor: | S. Krasnenko, A. Starkova, Shandor Erdes, E. Agafonova, M. Urumova, M. Podryadnova, D. Rumiantceva |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Ankylosing spondylitis
HLA-B27 medicine.medical_specialty business.industry Amyloidosis Immunology Enthesitis Arthritis medicine.disease General Biochemistry Genetics and Molecular Biology Rheumatology AA amyloidosis Psoriasis Internal medicine medicine Immunology and Allergy medicine.symptom business Uveitis |
| Zdroj: | Annals of the Rheumatic Diseases. 79:1654.2-1655 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2020-eular.3209 |
| Popis: | Background:Secondary AA-amyloidosis is one of the most serious complications of ankylosing spondylitis (AS). Better knowledge of specific to secondary AA-amyloidosis clinical features is important for improving further management of these patients.Objectives:To conduct a comparative analysis of AS patients with and without secondary AA-amyloidosis.Methods:The study included 220 AS patients (according to modified New York criteria) without amyloidosis - Group 1, and 9 AS patients with histologically confirmed secondary AA-amyloidosis – Group 2.Results:Table 1 presents the comparative characteristics of Group 1 and Group 2 patients. Both groups were comparable in terms of patients’ age, rates of HLA B27 positivity, presence of enthesitis, uveitis, inflammatory bowel diseases (IBD), and psoriasis on assessment. Group 2 patients tended to be younger at AS onset, while shorter disease duration and fewer male patients were established for Group 1. Group 2 had higher rates of extra-spinal AS manifestations, such as arthritis and coxitis. It should be noted that all AS patients with secondary AA-amyloidosis were males, with clinically manifest arthritis, involving hip joints, and AS onset in the childhood in 8 out of 9 cases.Table 1.Comparative characteristics of Group 1 and Group 2 AS patients.Group 1 (n=220)Group 2 (n=9)рMean age, M±α, y.35,1±9,540,1±8,6>0.05Mean age at the onset, M±α, y.29,9±9,613,4±7,5Mean disease duration, M±α, y.6,9±5,626,3±6,5Men, n (%)162 (73,6%)9 (100%)HLA B27, n (%)202 (91,8%)9 (100%)>0.05Arthritis, n (%)182 (82,7%)9 (100%)Coxitis, n (%)119 (54,0%)9 (100%)Enthesitis, n (%)105 (47,7%)7 (78%)>0.05Uveitis, n (%)52 (23,6%)4 (44,4%)>0.05IBD, n (%)5 (2,2%)0>0.05Psoriasis, n (%)24 (10,9%)0>0.05Conclusion:Patients with AS and secondary AA amyloidosis are predominantly of male gender, who usually get sick in childhood, have 100% HLA-B27 positivity, peripheral arthritis, and coxitis.Disclosure of Interests:None declared |
| Databáze: | OpenAIRE |
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